Volume 2, Issue 1 (2-2018)                   GMJ Medicine 2018, 2(1): 33-37 | Back to browse issues page

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Nazer M R, Darvishi M, Qolampour A. The Protective Role of Menthone Against Indomethacin-Induced Gastric Ulcers in Rat Model. GMJ Medicine. 2018; 2 (1) :33-37
URL: http://gmjpress.de/article-1-34-en.html
1- Department of Infectious Diseases, Hepatitis Research Center, Lorestan University of Medical ‎Sciences, Khorramabad, Iran
2- Infectious Diseases and Tropical Medicine Research Center (IDTMRC), AJA University of ‎Medical Sciences, Tehran, Iran
3- Resident of General Surgery, Department of General Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract:   (352 Views)
Background: The use of novel agents has been considered for management of different diseases. Gastric ulcer is a common disease. This study aimed to evaluate the effects of menthone, as a novel agent, on gastric ulcers in Indomethacin-induced model rat.
Methods: Animals were divided into 3 groups: 1) Control group that received only distilled water, 2) Animals were treated with 40 mg/kg bw omeprazole (Omeprazole) and 3) Animals were treated with 40 mg/kg bw menthone (Menthone). A single dose of indomethacin (30 mg/kg body weight) was administrated to per animal. Gastric secretions and antioxidant parameters were evaluated in the end of trial.
Results: It was observed that an increased ulcer index, gastric volume, malondialdehyde level and decreased super oxide dismutase and pepsin activity in control group in comparison to other groups (P<0.05). The use of menthone and Omeprazole could alleviate the effects of indomethacin.
Conclusion: Menthone may not have positive effects similar to Omeprazole, but it could attenuate effects of indomethacin. We recommend using of menthone, as an efficient agent, for treatment of gastric ulcer.
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Type of Study: Original Article | Subject: Pharmacology
Received: 2018/04/12 | Accepted: 2018/05/27 | Published: 2018/06/15

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