Volume 3, Issue 1 (2-2019)                   GMJ Medicine 2019, 3(1): 99-104 | Back to browse issues page

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Liang L, Qili L, Jun W, Yan Y, Hui L, Jie Y. Study on the SPARC Expression and Relationship with Survival in Colorectal Cancer Patients in Han, Buyi and Miao Race. GMJ Medicine. 2019; 3 (1) :99-104
URL: http://gmjpress.de/article-1-48-en.html
1- Department of Oncology, Third Affiliated Hospital of Guizhou Medical University , Guizhou province, P.R. China
Abstract:   (704 Views)
Objective: To investigate the SPARCexpression and relationship with survival in Colorectalcancer (CRC)patients in Han, Buyi and Miao race.
Methods: In our study, SPARC protein expression was detected in 90 available formalin-fixed paraffin-embedded (FFPE) tissues specimens from CRC patients in Han, Buyi and Miao race from the Third Affiliated Hospital of Guizhou Medical University by means of immunohistochemistry. According to the different expression of SPARC, the patients were divided into low expression group(SPARC score of 0+and 1+ ) and high expression group(SPARC score of 2+ and 3+ ).The correlations between the two groups in DFS and OS were analyzed,respectively.
Results: SPARC was mainly expressed in tumor cell cytoplasm and the positive rates of SPARC was 52.2% (47/90). There was no difference in the positive expression rate in the Han, Buyi and Miao race(P =0.87).SPARC expression was related to the pathological type (Adenocarcinoma). There was a marked associations  in DFS between  the low expression of SPARC group and high expression group (P=0.048, 0.047) in the Han and Miao ethnic. While the same result was no found in the Buyi race(P=0.176). There was no statistical significance in OS between the low expression of SPARC group and high expression group in the Buyi, Miao and Han race, respectively(P= 0.338, 0.424, 0.282).
Conclusion: SPARC was related withDFS in the Miao and Han race, while no correlation in the Buyi race.
Keywords: SPARC, Colorectal cancer, DFS, OS
Full-Text [PDF 431 kb]   (277 Downloads)    
Type of Study: Original Article | Subject: Cancer Biology
Received: 2019/03/12 | Accepted: 2019/05/20 | Published: 2019/05/25

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