Volume 2, Issue 1 (2-2018)                   GMJ Medicine 2018, 2(1): 39-44 | Back to browse issues page

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Kheirollahi A, Hatami S, Olfati A. Relation Between Novel Markers with Sperm Quality in Obese Rats . GMJ Medicine. 2018; 2 (1) :39-44
URL: http://gmjpress.de/article-1-35-en.html
1- Assistant Professor of Urology Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
2- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:   (128 Views)
Background: Obesity and inflammation stemmed from obesity basically affects fertility and male reproductive system by its negative effect on erectile dysfunction and semen variables. Novel factors could be used to determine the fertility and infertility. This study was conducted to evaluate the relation between novel markers with sperm quality in obese rats.
Methods: Animals were grouped into 2 groups including normal group received normal rat pellet diet for 12 weeks of intervention, while other group received a high fat diet. The serum concentrations of IL-1β, IL-6, IL-3, TNF-α, sialic acid, CRP, haptoglobin and fibrinogen were measured. Sperm motility was assessed.
Resuts: Results showed that progressive motility and non-progressive motility and immotile were respectively lower and higher in obese rats in comparison to control groups (P<0.05). It was observed positive correlation between inflammatory factors and immobility and negative correlation between progressive motility with inflammation (P<0.05). 
Conclusion: Pro-inflammatory factors had significant correlation with sperm quality and could be used as markers for infertility.
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Type of Study: Original Article | Subject: Basic Medicine
Received: 2018/05/23 | Accepted: 2018/07/15 | Published: 2018/07/25

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