Volume 3, Issue 1 (2-2019)                   GMJ Medicine 2019, 3(1): 132-138 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rabinovich A, Romanoff N, Mordvinov D, Ivanov M. The Effects of Oral Administration of Pulegone in Carbon Tetrachloride-Induced Oxidative Stress in Wistar Rats. GMJ Medicine. 2019; 3 (1) :132-138
URL: http://gmjpress.de/article-1-53-en.html
1- Pirogov Russian National Research Medical University, Moscow, Russia
2- Institute for Biomedical Research, Association of Pharmaceutical Research and Development, Kyiv, Ukraine
Abstract:   (228 Views)
Background: Carbon tetrachloride (CCl4) has been applied to induce the toxicity and hepatic fibrosis. Natural antioxidants are known as efficient and safe treatments for hepatotoxicity compared with synthetic antioxidants. This study aimed to evaluate the effects of oral administration of pulegone in carbon tetrachloride-induced oxidative stress in Wistar rats.
Methods: Twenty rats were randomly assigned into four groups including control animals that received olive oil, Toxic control that administrated with 30% CCl4, Pulegone-20 & 30 that administrated with pulegone 20 mg/kg and 30 mg/kg, respectively, with in along to 30% CCl4. The liver levels of total cholesterol, triacylglycerides, phospholipids, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and vitamins C and E were evaluated.
Results: Administration of CCl4 increased levels of cholesterol, triacylglycerides and lipid oxidation, but it also reduced levels of phospholipids, SOD, CAT, GSH, GPx, and vitamins C and E (P<0.05). Oral administration of pulegone, especially in the higher levels, could reverse negative effects of CCl4 (P<0.05).
Conclusion: Using pulegone is recommended for liver protection due to its vital therapeutic antioxidant properties.
Full-Text [PDF 635 kb]   (43 Downloads)    
Type of Study: Original Article | Subject: Herbal Therapy
Received: 2019/06/15 | Accepted: 2019/08/10 | Published: 2019/08/25

Add your comments about this article : Your username or Email:
CAPTCHA

© 2019 All Rights Reserved | GMJ Medicine